Search This Blog

Showing posts with label UNIT- 2 - NERVOUS SYSTEM AND ENDOCRINE SYSTEM. Show all posts
Showing posts with label UNIT- 2 - NERVOUS SYSTEM AND ENDOCRINE SYSTEM. Show all posts

Friday, May 6, 2011

ENDOCRINE SYSTEM









Endocrine System





The nervous system sends electrical messages to control and coordinate the body. The endocrine system has a similar job, but uses chemicals to “communicate”. These chemicals are known as hormones. A hormone is a specific messenger molecule synthesized and secreted by a group of specialized cells called an endocrine gland. These glands are ductless, which means that their secretions (hormones) are released directly into the bloodstream and travel to elsewhere in the body to target organs, upon which they act. Note that this is in contrast to our digestive glands, which have ducts for releasing the digestive enzymes.

Pheromones are also communication chemicals, but are used to send signals to other members of the same species. Queen bees, ants, and naked mole rats exert control of their respective colonies via pheromones. One common use for pheromones is as attractants in mating. Pheromones are widely studied in insects and are the basis for some kinds of Japanese beetle and gypsy moth traps. While pheromones have not been so widely studied in humans, some interesting studies have been done in recent years on pheromonal control of menstrual cycles in women. It has been found that pheromones in male sweat and/or sweat from another “dominant” female will both influence/regulate the cycles of women when smeared on their upper lip, just below the nose. Also, there is evidence that continued reception of a given man’s pheromone(s) by a woman in the weeks just after ovulation/fertilization can significantly increase the chances of successful implantation of the new baby in her uterus. Pheromones are also used for things like territorial markers (urine) and alarm signals.

Each hormone’s shape is specific and can be recognized by the corresponding target cells. The binding sites on the target cells are called hormone receptors. Many hormones come in antagonistic pairs that have opposite effects on the target organs. For example, insulin and glucagon have opposite effects on the liver’s control of blood sugar level. Insulin lowers the blood sugar level by instructing the liver to take glucose out of circulation and store it, while glucagon instructs the liver to release some of its stored supply to raise the blood sugar level. Much hormonal regulation depends on feedback loops to maintain balance and homeostasis.

There are three general classes (groups) of hormones. These are classified by chemical structure, not function.

steroid hormones including prostaglandins which function especially in a variety of female functions (aspirin inhibits synthesis of prostaglandins, some of which cause “cramps”) and the sex hormones all of which are lipids made from cholesterol,
amino acid derivatives (like epinephrine) which are derived from amino acids, especially tyrosine, and
peptide hormones (like insulin) which is the most numerous/diverse group of hormones.
The major human endocrine glands include:

the hypothalamus and pituitary gland





The pituitary gland is called the “master gland” but it is under the control of the hypothalamus. Together, they control many other endocrine functions. They secrete a number of hormones, especially several which are important to the female menstural cycle, pregnancy, birth, and lactation (milk production). These include follicle-stimulating hormone (FSH), which stimulates development and maturation of a follicle in one of a woman’s ovaries, and leutinizing hormone (LH), which causes the bursting of that follicle (= ovulation) and the formation of a corpus luteum from the remains of the follicle.
There are a number of other hypothalamus and pituitary hormones which affect various target organs.
One non-sex hormone secreted by the posterior pituitary is antidiuretic hormone or ADH. This hormone helps prevent excess water excretion by the kidneys. Ethanol inhibits the release of ADH and can, thus, cause excessive water loss. That’s also part of the reason why a group of college students who go out for pizza and a pitcher of beer need to make frequent trips to the restrooms. Diuretics are chemicals which interfere with the production of or action of ADH so the kidneys secrete more water. Thus diuretics are often prescribed for people with high blood pressure, in an attempt to decrease blood volume.
Another group of non-sex hormones that many people have heard of is the endorphins, which belong to the category of chemicals known as opiates and serve to deaden our pain receptors. Endorphins, which are chemically related to morphine, are produced in response to pain. The natural response to rub an injured area, such as a pinched finger, helps to release endorphins in that area. People who exercise a lot and push their bodies “until it hurts” thereby stimulate the production of endorphins. It is thought that some people who constantly over-exercise and push themselves too much may actually be addicted to their own endorphins which that severe exercise regime releases.

the thyroid gland


Thyroid hormones regulate metabolism, therefore body temperature and weight. The thyroid hormones contain iodine, which the thyroid needs in order to manufacture these hormones. If a person lacks iodine in his/her diet, the thyroid cannot make the hormones, causing a deficiency. In response to the body’s feedback loops calling for more thyroid hormones, the thyroid gland then enlarges to attempt to compensate (The body’s plan here is if it’s bigger it can make more, but that doesn’t help if there isn’t enough iodine.). This disorder is called goiter. Dietary sources of iodine include any “ocean foods” because ocean-dwelling organisms tend to accumulate iodine from the seawater, and would include foods like ocean fish (tuna) and seaweeds like kelp. Because of this, people who live near the ocean do not have as much of a problem with goiter as people who live inland and don’t have access to these foods. To help alleviate this problem in our country, our government began a program encouraging salt refiners to add iodine to salt, and encouraging people to choose to consume this iodized salt.

the pancreas


This organ has two functions. It serves as a ducted gland, secreting digestive enzymes into the small intestine. The pancreas also serves as a ductless gland in that the islets of Langerhans secrete insulin and glucagon to regulate the blood sugar level. The -islet cells secrete glucagon, which tells the liver to take carbohydrate out of storage to raise a low blood sugar level. The -islet cells secrete insulin to tell the liver to take excess glucose out of circulation to lower a blood sugar level that’s too high. If a person’s body does not make enough insulin (and/or there is a reduced response of the target cells in the liver), the blood sugar rises, perhaps out of control, and we say that the person has diabetes mellitus.

the adrenal glands

These sit on top of the kidneys. They consist of two parts, the outer cortex and the inner medulla. The medulla secretes epinephrine (= adrenaline) and other similar hormones in response to stressors such as fright, anger, caffeine, or low blood sugar. The cortex secretes corticosteroids such as cortisone. Corticosteroids are well-known as being anti-inflammatory, thus are prescribed for a number of conditions. However, these are powerful regulators that should be used with caution. Medicinal doses are typically higher than what your body would produce naturally, thus the person’s normal feedback loops suppress natural secretion, and it is necessary to gradually taper off the dosage to trigger the adrenal glands to begin producing on their own again. Because the corticosteroids suppress the immune system, their use can lead to increased susceptibility to infections, yet physicians typically prescribe them for people whose immune systems are hard at work trying to fight off some pathogen. For example, back when I was in grad school, I was diagnosed with mono, and the campus doctor prescribed penicillin and cortisone. Since mono is a virus and penicillin only is effective against some bacteria, about all it did was kill off the friendly bacteria in my body, therefore causing me to develop a bad case of thrush. At the same time, the cortisone was supressing my immune system so my body could not as efficiently fight off the mono and the thrush. People with high blood pressure should be leery of taking prescription corticosteroids: they are known to raise blood pressure, thus can cause things like strokes. My mother-in-law had high blood pressure and was being treated with diuretics. Her physician also had her on large doses of cortisone for her arthritis. While he was on vacation, she started having significant back pain and was referred to an orthopedic surgeon. This man decided the back pain was just due to arthritis, and without carefully checking on what dosage she was already taking, prescribed more cortisone. Simultaneously, because of difficulty walking due to her arthritis, she decided to decrease the amount of diuretics she was taking so she didn’t have to make as many “long” trips to the other end of the house. The combination of lowered dose of diuretics and high dose of cortisone raised her blood pressure to the point where a blood vessel in her brain burst, causing a stroke. When the EMTs took her blood pressure, as I recall the systolic was way over 200 mm Hg.

the gonads or sex organs


In addition to producing gametes, the female ovaries and male testes (singular = testis) also secrete hormones. Therefore, these hormones are called sex hormones. The secretion of sex hormones by the gonads is controlled by pituitary gland hormones such as FSH and LH. While both sexes make some of each of the hormones, typically male testes secrete primarily androgens including testosterone. Female ovaries make estrogen and progesterone in varying amounts depending on where in her cycle a woman is. In a pregnant woman, the baby’s placenta also secretes hormones to maintain the pregnancy.

the pineal gland

This gland is located near the center of the brain in humans, and is stimulated by nerves from the eyes. In some other animals, the pineal gland is closer to the skin and directly stimulated by light (some lizards even have a third eye). The pineal gland secreted melatonin at night when it’s dark, thus secretes more in winter when the nights are longer. Melatonin promotes sleep (makes you feel sleepy). It also affects reproductive functions by depressing the activity of the gonads. Additionally, it affects thyroid and adrenal cortex functions. In some animals, melatonin affects skin pigmentation. Because melatonin production is affected by the amount of light to which a person is exposed, this is tied to circadian rhythm (having an activity cycle of about 24 hours), annual cycles, and biological clock functions. SAD or seasonal affective disorder (syndrome) is a disorder in which too much melatonin is produced, especially during the long nights of winter, causing profound depression, oversleeping, weight gain, tiredness, and sadness. Treatment consists of exposure to bright lights for several hours each day to inhibit melatonin production. It has also been found that melatonin levels drop 75% suddenly just before puberty, suggesting the involvement of melatonin in the regulation of the onset of puberty. Studies have been done on blind girls (with a form of blindness in which no impulses can travel down the optic nerve and reach the brain and pineal gland), which showed that these girls tended to have higher levels of melatonin for a longer time, resulting in a delay in the onset of puberty. While some older people, who don’t make very much melatonin, thus don’t sleep well, might benefit from a melatonin supplement, I’m skeptical of the recent melatonin craze in this country. When so many people apparently are suffering from SAD, I question the wisdom of purposly ingesting more melatonin, especially since the pineal gland is one of the least-studied, least-understood of the endocrine glands.
Local regulators are hormones with target cells nearby or adjacent to the endocrine gland in question. For example, neurotransmitters are secreted in the synapses of our nervous system and their target cells are in the same synapses.




ENDOCRINE SYSTEM - YOGIC VIEW

First Chakra

The first chakra is located at the base of the spine, it is said that the Kundalini serpent (Shakti) lies coiled there waiting to be released and Merged with Shiva in the crown center. The color of this base energy center is red and its orientation is that of survival. It is the animal instinct which lies within all of us that urges us to survive.

People that do not have enough flow of energy through this chakra do not feel as though they are secure in the world, there daily life is a battle just to stay above water and they are typically on edge.

This center has to due with elimination, when energy flows freely through this center one is able to release, and let go, of that which could slow them down.

Benefits of a Balanced First Chakra

Sense of groundedness
Security
A stable base from which to move forward
The 1st chakra is ever so important because it allows us to feel connected to the earth. It is the first chakra that tells us to walk bare foot on the beach, it is the first charkra that tells us nature is a beautiful thing. And it is the 1st chakra that helps those more spiritually inclined to keep their feet on the ground as their head dances in the clouds

Second Chakra- Svadhisthana

The second chakra is located just above the base of the spine around ones sex organs. This energy center has to do with creativity, specifically around the creation of life. Orange is the color of the 2nd Chakra. There is a large imbalance in our society in the second center due to mass media glorifying sexuality, without the presence of love

When this chakra is blocked it manifests itself with a deep sense of insecurity with ones own sexuality. A person with an over active 2nd chakra will tend to focus on sex too much.

The second chakra builds upon the survival instincts of the 1st chakra, by Desire. The desire to pass along our genetic blue print and produce off spring.

Benefits of a Balanced 2nd Chakra
Proper flow of energy through reproductive organs
Healthy sex life
Ability to properly focus creative energy
Once one has properly balanced the sacral center they are able to transmute the creative energies of the second chakra into the higher centers and express the divine creativity from within.

Third Chakra- Manipura (Personal Power)

The 3rd Chakra is located in the belly. It is the seat of ones personal power. It directly affects ones ability to project their will into manifestation. This center is one that is constantly challenged in humanity . The majority of people are constantly having their power chakras challenged weather it be at work, in our relationships, or simply within ourselves. Power struggles are contsant in our daily grind. An under active third chakra can lead to a true feeling of powerlessness. An over active 3rd center can be just as detrimental as an under active one and may result in the over powering of others, typically for selfish desire.
The root of this problem stems from not transfering the energy of the 3rd center up through the heart center. The power that stems from the third chakra, balanced in love will lead humanity to a grand state of peace and well being.

The 3rd center is commonly associated with the “core” balancing activities that many aerobics focus on. The focus on this core, or power center, allows people to feel in control of their own destiny. As it is located in the belly it is also tied into the digestive system. When we are stressed we tend to get indigestion, which is merely a symptom of an unbalanced 3rd chakra.
This energy center is typically associated with the color Yellow, or Gold.

Benefits of a Balanced 3rd Chakra
Properly porportioned sense of self
Ability to influence/change ones surrounding environment
Strong digestive system
Core stability
As the power center this chakra helps to regulate the flow of energy to the other centers. By clearing this chakra of imbalances we can operate powerfully in our environment. This leads to an improved sense of self, and self esteem, which in turns increases our ability to help others.


Fourth Chakra- Anahata (Heart Center)


The 4th chakra lies between the shoulder blades slightly higher than the physical heart.

The focus of the heart center is non other than love and balance. It is from within the heart center that the Lord of Love shines forth in all of us. The heart center plays an important role in the balancing of the chakra system. In order to achieve a proper balance and flow of energy through the chakras, that energy must be integrated across the heart center. The blending of the higher and lower centers, (though each equally important) must be acheived across the heart center.

One means of achieving balance across the charka system is to take an inventory of what centers are out of balance. See to it that as you work on balancing each of those centers that you even out the balancing across the heart center. If weeek 1 you work on your 1st Chakra, and your 7th Chakra is out of balance as well, then try working on your 7th Chakra the next week. As you work with these energy centers you will find that the blockages move as your life moves. I speak only from my own personal experience in working with these centers over the past couple of years, (in this life time.)

When a person is blocked in the Heart Center it may manifest as a lack of abilty to give freely, or a lack of resources. The Heart Center tends to be an area that humanity requires the most healing in, who hasn’t been hurt by a loving relationship in the past. An ironic twist is that the Heart Center is also the primary center from which healing flows.
The color of the fourth chakra, is green. Green the color of abundance and good fortune. Pink is another potential color for this center, which represents a balancing of the White Light from above with the Red of the 1st Chakra.

Benefits of a Balanced Fourth Chakra
Love
Ability to give freely to others
Abundance
Healing for ones self and others
Integration of the higher and lower energy centers
Meditation from the Heart Center is an excellent means of polling our higher selves for what is right. If you hear your heart speak it to you then follow it. I have been working on allowing my heart to guide me for sometime, which is challenging considering my head likes to think it controls things The path may not be the one most easily taken, but listening to and operating from the heart center will help you to achieve your purpose.
The Heart Center represents Love. What a fantastic quailty to work on balancing

Thyroid Disease

It has come to my attention that a good number of individuals suffer from Thyroid Disease, of some sort or another, and it appears as though women are more likely to have difficulties than men. Weather it is an underactive thyroid, or an overactive thyroid the imbalance in the endocrine system is simply devistating to ones health. This ailment faces my mother and one of my co-workers as well, so it really hits home for me.

As I work through my studies of Kundalini Yoga I am researching the human endocrine system, and outlining some thoughts for chakra-neuroendocrinology, (a science that the yogis have understood for some time, but requires additional Western study.)

My study now takes me to the Thyroid. I seek to gain an understanding of its function and make the case for Kundalini Yoga as a Preventative Maintenance program to keep thyroid disease and disorders away. (Yoga is a maintenance program for the body, mental, emotional and spiritual, as well, but let’s stay focused on this aspect for the time.)

In my previous post on chakra-neuroendocrinology I referenced a resource book that is helping me understand the system. My high level overviews of the tyroid, based on the book, and other insights are as follows:

The thyroid is related to the 5th chakra, or center of communication located around the throat. It is good to keep in mind that the element associated with the 5th chakra is ether. Technically speaking all of our chakras are rooted on the subtle plane of the ethers and bridge the vital gap into physical manifestation. But the 5th chakra is of much interest to etheric relations. It makes one ponder upon the etheric implications of under active and over active 5th chakras.

The human thyroid is the gland that is very closely associated with metabolism. “A primary role of the thyroid is to increase energy expenditure and thermo-genesis.”
That being said the pituitary gland, (or Master Gland,) is responsible for stimulating the thyroid hormone secretion. An imbalance in the thyroid or pituitary gland can lead to challenges in the system.

Hypothyroidism- Underactive thyroid

This implies an individual has thyroid hormone levels that are too low for proper flow in the endocrine system. A common cause of this is the presence of antithyroid antibodies. A common symptom of this is sluggishness, (yoga helps make the body move.)
Hyperthyrodism- Overactive thyroid

This implies that an individual has thyroid levels that are higher than appropriate for the proper flow of energy. There are technically 2 types of this disorder, the type that is caused from within the body and the type that is caused from outside of the body. A common symptom of this is weight loss. This dis-ease can also lead to increased speed in mental processes, but with the propensity to create errors within the thinking. Again, one cause of this is a mis-aligned anti body within the system.

Preventative Thyroid Maintenance
It is my thinking that Yoga, (I am partial to Kundalini but all forms of Yoga are appropriate,) is the optimal means of preventing thyroid disease and disorders. It’s kind of like a car, one takes in their car on a regular basis so that maintenance work can be done. The result of this maintenance is a car that runs smoother, lasts longer and is less likely to die on you. The same is true of the human body and they thyroid.

Kundalini Yoga provides lovely specific means to maintain proper balance within the thyroid. The best way to cure thyroid disease is to never allow the root cause to develop in the first place, thus I stress maintenance.

Food that nurtures the Thyroid
Eating the right foods is also important for proper flow through the thyroid. Mark Hyman M.D. has noticed that thyroid disorders are on the rise, and he brings an interesting and valid perspective as to the cause. He focuses more on the environmental and dietary factors that enter into the thyroid system:

“For example, food allergies, like sensitivities to gluten and other foods, also negatively affect thyroid function-and are frequently undiagnosed. Likewise, deficiencies in nutrients important to good thyroid function-like selenium, zinc, omega-3 fatty acids. and iodine and tyrosine-can trigger thyroid problems.”

Fight Thyroid Disease
Mark Hyman has very sound tips for fighting thyroid disease. I would suggest that we focus on preventing them in the first place.

But if you find yourself in a situation where you need to fight the dis-ease review his suggestions and might I suggest integrating a strong Kundalini Yoga practice into your life cycle.

I have another future proposed test for testing the validity of healing via chakra-neuroendocrinology. There are a couple tests that can be done to measure the levels of thyroid hormones in ones system. I propose a controlled test with 3 groups:

Group of people with over active thyroid (n=60)
Group of peoplw with under active thyroid (n=60)
Control group (n=60)
Measure the levels of thyroid hormone prior to testing. One half of each group will live out their lives normally, or under go the typical Western treatment. The second half will practice Kundalini Yoga on a Daily basis with a strong focus on 5th chakra exercizes and a little 6th chakra work here and ther. (We could add thyroid specific eating into the equation at a future date perhaps.)

I find it interesting that one of my first major energetic blockages in this life time, that I was consciously aware of, was in my throat center. (Sarah, thanks again for the release.)

The timing of this post is also rather interesting, as I am 18 days into a 40 Kundalini Yoga kriya that focuses on the 5th chakra.

Sixth Chakra- Ajna (

Center of Intution or Third Eye)
The ajna center is located directly in ones brow, between the eyebrows on the forehead. This center is commonly called the Third eye. As the third eye opens one is able to access their intuition at a much higher level.

The sixth chakra is also provides a channel for projection of energy, more specifically thought energy. As one starts actively working with the Third Eye sensations, or impressions, begin to register with the conscious mind right in the forehead. One may speak of it as reinforcing ones forehead

When there is not sufficient energy flowing into this center one will have challenges projecting their thoughts into the world of manifestation. They will also have difficulties with their sense of intuition.
People that have an overactive Third Eye may be too mental in nature. They can focus too much of their attention within their own mind and can come off as aloof.
The color of the 6th chakra is a blend of electric blue meets deep purple.

Benefits of a Balanced 6th Chakra
Improved intuition
Ability to swiftly transition into a meditative state
Psychic ability
Thought projection into manifestation
The sixth chakra has much potential to increase the quality of our lives when properly balanced. As humanity evolves the power of the sixth center will be with us. The ability to focus within the mind and bring down impressions from above is truly inspiring


Seventh Chakra- Sahasrara- Crown


The 7th chakra is our connection to the divine. It has been called the thousand petal lotus by many. The seventh center is located at the top of ones head, where the soft spot is located on a baby. It is from this center that we are connected to our souls, and all souls, through the rainbow bridge.

The color of the seventh chakra is light purple, or violet. It is also closely associated with white, or divine, light from above.

Yoga, is a study of Union. It can be said that Kundalini Yoga focuses on the union and balance of the 1st chakra flowing up through the etheric system and merging in the crown chakra.

When the seventh chakra is blocked it impeeds the flow of divine light to flow through our being. It becomes challenging for us to aknowledge the divine within all forms, (Sat Nam, Namaste.) Our relationship with G.O.D is not centered. For those of you who science of prime importance, Generating Energy, Organizing Energy and Destroying/Delivering Energy.

Those with an overactive crown chakra that is not balanced across the heart center may be prone to being not of the world from time to time. Flighty, or aloof come to mind. One that is properly centered is able to operate in the world, but not be of the world.

Benefits of a balanced 7th Chakra
Connection with ones soul
Ability to realize soul purpose
Meditative prowless
Aknowledgement of the divine within all form
Close relationship with G.O.D.
Knowing and walking ones path
The crown chakra represents a location of great spiritual potential. But this is not the only focus of Yoga. All things must come to balance. While participating on the earth school the energies of the 7th center and the connection with the soul must merge with the rest of our being. And from this union peace may be known

NERVOUS SYSTEM

THE NERVOUS SYSTEM



The Neuron |Nervous tissue is composed of two main cell types: neurons and glial cells. Neurons transmit nerve messages. Glial cells are in direct contact with neurons and often surround them.


Nerve Cells and Astrocyte (SEM x2,250). This image is copyright Dennis Kunkel at www.DennisKunkel.com, used with permission.

The neuron is the functional unit of the nervous system. Humans have about 100 billion neurons in their brain alone! While variable in size and shape, all neurons have three parts. Dendrites receive information from another cell and transmit the message to the cell body. The cell body contains the nucleus, mitochondria and other organelles typical of eukaryotic cells. The axon conducts messages away from the cell body.


Structure of a typical neuron.

Three types of neurons occur. Sensory neurons typically have a long dendrite and short axon, and carry messages from sensory receptors to the central nervous system. Motor neurons have a long axon and short dendrites and transmit messages from the central nervous system to the muscles (or to glands). Interneurons are found only in the central nervous system where they connect neuron to neuron.


Structure of a neuron and the direction of nerve message transmission. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Some axons are wrapped in a myelin sheath formed from the plasma membranes of specialized glial cells known as Schwann cells. Schwann cells serve as supportive, nutritive, and service facilities for neurons. The gap between Schwann cells is known as the node of Ranvier, and serves as points along the neuron for generating a signal. Signals jumping from node to node travel hundreds of times faster than signals traveling along the surface of the axon. This allows your brain to communicate with your toes in a few thousandths of a second.


Cross section of myelin sheaths that surround axons (TEM x191,175). This image is copyright Dennis Kunkel at www.DennisKunkel.com, used with permission.



The Nerve Message
The plasma membrane of neurons, like all other cells, has an unequal distribution of ions and electrical charges between the two sides of the membrane. The outside of the membrane has a positive charge, inside has a negative charge. This charge difference is a resting potential and is measured in millivolts. Passage of ions across the cell membrane passes the electrical charge along the cell. The voltage potential is -65mV (millivolts) of a cell at rest (resting potential). Resting potential results from differences between sodium and potassium positively charged ions and negatively charged ions in the cytoplasm. Sodium ions are more concentrated outside the membrane, while potassium ions are more concentrated inside the membrane. This imbalance is maintained by the active transport of ions to reset the membrane known as the sodium potassium pump. The sodium-potassium pump maintains this unequal concentration by actively transporting ions against their concentration gradients.



.

Nervous Systems

Multicellular animals must monitor and maintain a constant internal environment as well as monitor and respond to an external environment. In many animals, these two functions are coordinated by two integrated and coordinated organ systems: the nervous system and the endocrine system. Click here for a diagram of the Nervous System.

Three basic functions are prformed by nervous systems:

Receive sensory input from internal and external environments
Integrate the input
Respond to stimuli
Sensory Input
Receptors are parts of the nervous system that sense changes in the internal or external environments. Sensory input can be in many forms, including pressure, taste, sound, light, blood pH, or hormone levels, that are converted to a signal and sent to the brain or spinal cord.

Integration and Output
In the sensory centers of the brain or in the spinal cord, the barrage of input is integrated and a response is generated. The response, a motor output, is a signal transmitted to organs than can convert the signal into some form of action, such as movement, changes in heart rate, release of hormones, etc.

Endocrine Systems
Some animals have a second control system, the endocrine system. The nervous system coordinates rapid responses to external stimuli. The endocrine system controls slower, longer lasting responses to internal stimuli. Activity of both systems is integrated.

Divisions of the Nervous System
The nervous system monitors and controls almost every organ system through a series of positive and negative feedback loops.The Central Nervous System (CNS) includes the brain and spinal cord. The Peripheral Nervous System (PNS) connects the CNS to other parts of the body, and is composed of nerves (bundles of neurons).

Not all animals have highly specialized nervous systems. Those with simple systems tend to be either small and very mobile or large and immobile. Large, mobile animals have highly developed nervous systems: the evolution of nervous systems must have been an important adaptation in the evolution of body size and mobility.

Coelenterates, cnidarians, and echinoderms have their neurons organized into a nerve net. These creatures have radial symmetry and lack a head. Although lacking a brain or either nervous system (CNS or PNS) nerve nets are capable of some complex behavior.


Nervous systems in radially symmetrical animals. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Bilaterally symmetrical animals have a body plan that includes a defined head and a tail region. Development of bilateral symmetry is associated with cephalization, the development of a head with the accumulation of sensory organs at the front end of the organism. Flatworms have neurons associated into clusters known as ganglia, which in turn form a small brain. Vertebrates have a spinal cord in addition to a more developed brain.


Some nervous systems in bilaterally symmetrical animals. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Chordates have a dorsal rather than ventral nervous system. Several evolutionary trends occur in chordates: spinal cord, continuation of cephalization in the form of larger and more complex brains, and development of a more elaborate nervous system. The vertebrate nervous system is divided into a number of parts. The central nervous system includes the brain and spinal cord. The peripheral nervous system consists of all body nerves. Motor neuron pathways are of two types: somatic (skeletal) and autonomic (smooth muscle, cardiac muscle, and glands). The autonomic system is subdivided into the sympathetic and parasympathetic systems.

Peripheral Nervous System

The Peripheral Nervous System (PNS)contains only nerves and connects the brain and spinal cord (CNS) to the rest of the body. The axons and dendrites are surrounded by a white myelin sheath. Cell bodies are in the central nervous system (CNS) or ganglia. Ganglia are collections of nerve cell bodies. Cranial nerves in the PNS take impulses to and from the brain (CNS). Spinal nerves take impulses to and away from the spinal cord. There are two major subdivisions of the PNS motor pathways: the somatic and the autonomic.

Two main components of the PNS:

sensory (afferent) pathways that provide input from the body into the CNS.
motor (efferent) pathways that carry signals to muscles and glands (effectors).
Most sensory input carried in the PNS remains below the level of conscious awareness. Input that does reach the conscious level contributes to perception of our external environment.

Somatic Nervous System | Back to Top
The Somatic Nervous System (SNS) includes all nerves controlling the muscular system and external sensory receptors. External sense organs (including skin) are receptors. Muscle fibers and gland cells are effectors. The reflex arc is an automatic, involuntary reaction to a stimulus. When the doctor taps your knee with the rubber hammer, she/he is testing your reflex (or knee-jerk). The reaction to the stimulus is involuntary, with the CNS being informed but not consciously controlling the response. Examples of reflex arcs include balance, the blinking reflex, and the stretch reflex.

Sensory input from the PNS is processed by the CNS and responses are sent by the PNS from the CNS to the organs of the body.

Motor neurons of the somatic system are distinct from those of the autonomic system. Inhibitory signals, cannot be sent through the motor neurons of the somatic system.

Autonomic Nervous System

The Autonomic Nervous System is that part of PNS consisting of motor neurons that control internal organs. It has two subsystems. The autonomic system controls muscles in the heart, the smooth muscle in internal organs such as the intestine, bladder, and uterus. The Sympathetic Nervous System is involved in the fight or flight response. The Parasympathetic Nervous System is involved in relaxation. Each of these subsystems operates in the reverse of the other (antagonism). Both systems innervate the same organs and act in opposition to maintain homeostasis. For example: when you are scared the sympathetic system causes your heart to beat faster; the parasympathetic system reverses this effect.

Motor neurons in this system do not reach their targets directly (as do those in the somatic system) but rather connect to a secondary motor neuron which in turn innervates the target organ.



Central Nervous System
The Central Nervous System (CNS) is composed of the brain and spinal cord. The CNS is surrounded by bone-skull and vertebrae. Fluid and tissue also insulate the brain and spinal cord.


Areas of the brain. The above image is from http://www.prs.k12.nj.us/schools/PHS/Science_Dept/APBio/pic/brain.gif.

The brain is composed of three parts:

the cerebrum (seat of consciousness), the cerebellum, and the medulla oblongata (these latter two are "part of the unconscious brain").

The medulla oblongata is closest to the spinal cord, and is involved with the regulation of heartbeat, breathing, vasoconstriction (blood pressure), and reflex centers for vomiting, coughing, sneezing, swallowing, and hiccuping. The hypothalamus regulates homeostasis. It has regulatory areas for thirst, hunger, body temperature, water balance, and blood pressure, and links the Nervous System to the Endocrine System. The midbrain and pons are also part of the unconscious brain. The thalamus serves as a central relay point for incoming nervous messages.

The cerebellum is the second largest part of the brain, after the cerebrum. It functions for muscle coordination and maintains normal muscle tone and posture. The cerebellum coordinates balance.

The conscious brain includes the cerebral hemispheres, which are are separated by the corpus callosum. In reptiles, birds, and mammals, the cerebrum coordinates sensory data and motor functions. The cerebrum governs intelligence and reasoning, learning and memory. While the cause of memory is not yet definitely known, studies on slugs indicate learning is accompanied by a synapse decrease. Within the cell, learning involves change in gene regulation and increased ability to secrete transmitters.

The Brain

During embryonic development, the brain first forms as a tube, the anterior end of which enlarges into three hollow swellings that form the brain, and the posterior of which develops into the spinal cord. Some parts of the brain have changed little during vertebrate evolutionary history. Click here to view an diagram of the brain, and here for a clickable map of the brain.


Parts of the brain as seen from the middle of the brain. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Vertebrate evolutionary trends include

Increase in brain size relative to body size.
Subdivision and increasing specialization of the forebrain, midbrain, and hindbrain.
Growth in relative size of the forebrain, especially the cerebrum, which is associated with increasingly complex behavior in mammals.
The Brain Stem and Midbrain
The brain stem is the smallest and from an evolutionary viewpoint, the oldest and most primitive part of the brain. The brain stem is continuous with the spinal cord, and is composed of the parts of the hindbrain and midbrain. The medulla oblongata and pons control heart rate, constriction of blood vessels, digestion and respiration.

The midbrain consists of connections between the hindbrain and forebrain. Mammals use this part of the brain only for eye reflexes.

The Cerebellum
The cerebellum is the third part of the hindbrain, but it is not considered part of the brain stem. Functions of the cerebellum include fine motor coordination and body movement, posture, and balance. This region of the brain is enlarged in birds and controls muscle action needed for flight.

The Forebrain
The forebrain consists of the diencephalon and cerebrum. The thalamus and hypothalamus are the parts of the diencephalon. The thalamus acts as a switching center for nerve messages. The hypothalamus is a major homeostatic center having both nervous and endocrine functions.

The cerebrum,

the largest part of the human brain, is divided into left and right hemispheres connected to each other by the corpus callosum. The hemispheres are covered by a thin layer of gray matter known as the cerebral cortex, the most recently evolved region of the vertebrate brain. Fish have no cerebral cortex, amphibians and reptiles have only rudiments of this area.

The cortex in each hemisphere of the cerebrum is between 1 and 4 mm thick. Folds divide the cortex into four lobes: occipital, temporal, parietal, and frontal. No region of the brain functions alone, although major functions of various parts of the lobes have been determined.


The major brain areas and lobes. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

The occipital lobe (back of the head) receives and processes visual information. The temporal lobe receives auditory signals, processing language and the meaning of words. The parietal lobe is associated with the sensory cortex and processes information about touch, taste, pressure, pain, and heat and cold. The frontal lobe conducts three functions:

motor activity and integration of muscle activity
speech
thought processes

Functional areas of the brain. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Most people who have been studied have their language and speech areas on the left hemisphere of their brain. Language comprehension is found in Wernicke's area. Speaking ability is in Broca's area. Damage to Broca's area causes speech impairment but not impairment of language comprehension. Lesions in Wernicke's area impairs ability to comprehend written and spoken words but not speech. The remaining parts of the cortex are associated with higher thought processes, planning, memory, personality and other human activities.


Parts of the cerebral cortex and the relative areas that are devoted to controlling various body regions. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

The Spinal Cord

The spinal cord runs along the dorsal side of the body and links the brain to the rest of the body. Vertebrates have their spinal cords encased in a series of (usually) bony vertebrae that comprise the vertebral column.

The gray matter of the spinal cord consists mostly of cell bodies and dendrites. The surrounding white matter is made up of bundles of interneuronal axons (tracts). Some tracts are ascending (carrying messages to the brain), others are descending (carrying messages from the brain). The spinal cord is also involved in reflexes that do not immediately involve the brain.

The Brain and Drugs

Some neurotransmitters are excitory, such as acetylcholine, norepinephrine, serotonin, and dopamine. Some are associated with relaxation, such as dopamine and serotonin. Dopamine release seems related to sensations of pleasure. Endorphins are natural opioids that produce elation and reduction of pain, as do artificial chemicals such as opium and heroin. Neurological diseases, for example Parkinson's disease and Huntington's disease, are due to imbalances of neurotransmitters. Parkinson's is due to a dopamine deficiency. Huntington's disease is thought to be cause by malfunctioning of an inhibitory neurotransmitter. Alzheimer's disease is associated with protein plaques in the brain.

Drugs are stimulants or depressants that block or enhance certain neurotransmitters. Dopamine is thought involved with all forms of pleasure. Cocaine interferes with uptake of dopamine from the synaptic cleft. Alcohol causes a euphoric "high" followed by a depression.

Marijuana, material from the Indian hemp plant (Cannabis sativa), has a potent chemical THC (tetrahydracannibinol) that in low, concentrations causes a euphoric high (if inhaled, the most common form of action is smoke inhalation). High dosages may cause severe effects such as hallucinations, anxiety, depression, and psychotic symptoms.

Cocaine is derives from the plant Erthoxylon coca. Inhaled, smoked or injected. Cocaine users report a "rush" of euphoria following use. Following the rush is a short (5-30 minute) period of arousal followed by a depression. Repeated cycle of use terminate in a "crash" when the cocaine is gone. Prolonged used causes production of less dopamine, causing the user to need more of the drug.

Heroin is a derivative of morphine, which in turn is obtained from opium, the milky secretions obtained from the opium poppy, Papaver somniferum. Heroin is usually injected intravenously, although snorting and smoking serve as alternative delivery methods. Heroin binds to ophioid receptors in the brain, where the natural chemical endorphins are involved in the cessation pain. Heroin is physically addictive, and prolonged use causes less endorphin production. Once this happens, the euphoria is no longer felt, only dependence and delay of withdrawal symptoms.

Senses

Input to the nervous system is in the form of our five senses: pain, vision, taste, smell, and hearing. Vision, taste, smell, and hearing input are the special senses. Pain, temperature, and pressure are known as somatic senses. Sensory input begins with sensors that react to stimuli in the form of energy that is transmitted into an action potential and sent to the CNS.

Sensory Receptors
Sensory receptors are classified according to the type of energy they can detect and respond to.
Mechanoreceptors: hearing and balance, stretching.
Photoreceptors: light.
Chemoreceptors: smell and taste mainly, as well as internal sensors in the digestive and circulatory systems.
Thermoreceptors: changes in temperature.
Electroreceptors: detect electrical currents in the surrounding environment.
Mechanoreceptors vary greatly in the specific type of stimulus and duration of stimulus/action potentials. The most adaptable vertebrate mechanoreceptor is the hair cell. Hair cells are present in the lateral line of fish. In humans and mammals hair cells are involved with detection of sound and gravity and providing balance.

Hearing
Hearing involves the actions of the external ear, eardrum, ossicles, and cochlea. In hearing, sound waves in air are converted into vibrations of a liquid then into movement of hair cells in the cochlea. Finally they are converted into action potentials in a sensory dendrite connected to the auditory nerve. Very loud sounds can cause violent vibrations in the membrane under hair cells, causing a shearing or permanent distortion to the cells, resulting in permanent hearing loss.

Orientation and Gravity
Orientation and gravity are detected at the semicircular canals. Hair cells along three planes respond to shifts of liquid within the cochlea, providing a three-dimensional sense of equilibrium. Calcium carbonate crystals can shift in response to gravity, providing sensory information about gravity and acceleration.

Photoreceptors Detect Vision and Light Sensitivity
The human eye can detect light in the 400-700 nanometer (nm) range, a small portion of the electromagnetic spectrum, the visible light spectrum. Light with wavelengths shorter than 400 nm is termed ultraviolet (UV) light. Light with wavelengths longer than 700 nm is termed infrared (IR) light.


The electromagnetic spectrum. Image from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman (www.whfreeman.com), used with permission.

Eye
In the eye, two types of photoreceptor cells are clustered on the retina, or back portion of the eye. These receptors, rods and cones, apparently evolved from hair cells. Rods detect differences in light intensity; cones detect color. Rods are more common in a circular zone near the edge of the eye. Cones occur in the center (or fovea centralis) of the retina.

Light reaching a photoreceptor causes the breakdown of the chemical rhodopsin, which in turn causes a membrane potential that is transmitted to an action potential. The action potential transfers to synapsed neurons that connect to the optic nerve. The optic nerve connects to the occipital lobe of the brain.

Humans have three types of cones, each sensitive to a different color of light: red, blue and green. Opsins are chemicals that bind to cone cells and make those cells sensitive to light of a particular wavelength (or color). Humans have three different form of opsins coded for by three genes on the X chromosome. Defects in one or more of these opsin genes can cause color blindness, usually in males.

Links | Back to Top
Nervous System Java Animation Net Doctor...you will need a Java-enabled browser to view the animation or you can download the AVI file.
Parkinson's Disease Information Page
Clickable Map of the Brain